Objectives : Vespae Nidus(VN1) has been used for inflammatory disease, pain disease, skin disease and some kind of cancer in folk remedy. In order to investigate the effect of anti-oxidation of Vespae Nidus, this study was done.
Methods : VN1 were investigated effects of antioxidation for DPPH(electron donating ability) radical ability, nitrate reductase(NR) activity, superoxide dismutase(SOD) sctivity, catalase activity, lipid peroxidase(LP) and glutathione(GSH).
Results : In vitro, DPPH radical ability was not significantly increased to the level of BHT. But NR activity was significantly increased to the level of BHT.
In vivo, compared with normal group, SOD activity and catalase activity were decreased in the acetaminophen treated group. On the other hand, VN1 in the pretreated groups SOD activity and catalase activity were significantly increased.
Compared with normal group, lipid peroxidation was increased in acetaminophen treated group. On the other hand, VN1 in the pretreated groups were decreased.
In the acetaminophen treated group, GSH activity was decreased by compare with normal group. And in the VN1 pretreated groups, GSH activity was increased to the control group.
Conclusion : According to the above results, the antioxidant action of Vespae Nidus is effective. And it is expected to be necessary to the study of the mechanism in the antioxidant of Vespae Nidus
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